Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment.

@article{Hutchings2014MonoclonalAR,
  title={Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment.},
  author={Catherine J. Hutchings and Gabriella Cseke and Greg J Osborne and Jeanette Woolard and Andrei Zhukov and Markus Koglin and Ali Jazayeri and Jahnavi Pandya-Pathak and Christopher James Langmead and Stephen J Hill and Malcolm Weir and Fiona H Marshall},
  journal={mAbs},
  year={2014},
  volume={6 1},
  pages={246-61}
}
Thermostabilized G protein-coupled receptors used as antigens for in vivo immunization have resulted in the generation of functional agonistic anti-β1-adrenergic (β1AR) receptor monoclonal antibodies (mAbs). The focus of this study was to examine the pharmacology of these antibodies to evaluate their mechanistic activity at β1AR. Immunization with the β1AR stabilized receptor yielded five stable hybridoma clones, four of which expressed functional IgG, as determined in cell-based assays used to… CONTINUE READING
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