Monoclonal and polyclonal gammopathy measured by serum free light chain and immunofixation subdivide the clinical outcomes of diffuse large B-cell lymphoma according to molecular classification

@article{Kim2014MonoclonalAP,
  title={Monoclonal and polyclonal gammopathy measured by serum free light chain and immunofixation subdivide the clinical outcomes of diffuse large B-cell lymphoma according to molecular classification},
  author={Yu Ri Kim and Soo-jeong Kim and June-Won Cheong and Yundeok Kim and Ji Eun Jang and Jung Yeon Lee and Yoo Hong Min and Jae-Woo Song and Woo Ick Yang and Jin Seok Kim},
  journal={Annals of Hematology},
  year={2014},
  volume={93},
  pages={1867-1877}
}
Elevated serum free light chain (FLC) is known to be an adverse prognostic factor for diffuse large B-cell lymphoma (DLBCL). We hypothesized that monoclonal gammopathy (MG; elevated kappa [κ] or lambda [λ] FLC with an abnormal κ/λ ratio or a positive IF [immunofixation]) and polyclonal gammopathy (PG; elevated κ and/or λ FLC with a normal κ/λ ratio and a negative IF) would have different clinical outcome according to the molecular classification of DLBCL. In addition, MG would be a poor… CONTINUE READING

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