Monoclonal Antibody Recognizing a Core Epitope on Mucin

@inproceedings{Devine1998MonoclonalAR,
  title={Monoclonal Antibody Recognizing a Core Epitope on Mucin},
  author={Peter Augustus Devine and Rachel J. Quin and Paul W Shield and Yew Wah Liew and John Kieran Sheehan and David E. Thornton},
  booktitle={Disease markers},
  year={1998}
}
Monoclonal antibody TH1 (IgM) was prepared by immunizing mice with deglycosylated (TFMSA-treated) cystic fibrosis mucin. TH1 reacted strongly with TFMSA treated cystic fibrosis mucin but not with the fully glycosylated mucin, indicating reactivity with a core mucin epitope. TH1 showed no reactivity with ovine mucin (98% of glycans as sialyl-Tn) but reacted strongly with desialylated ovine mucin, indicating the epitope for this mab was the Tn-antigen (O-linked GalNAc). However, TH1 showed no… CONTINUE READING

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