Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

  title={Monoclonal Antibody Pharmacokinetics and Pharmacodynamics},
  author={W. Wang and E. Q. Wang and J. Balthasar},
  journal={Clinical Pharmacology & Therapeutics},
  • W. Wang, E. Q. Wang, J. Balthasar
  • Published 2008
  • Medicine
  • Clinical Pharmacology & Therapeutics
  • More than 20 monoclonal antibodies have been approved as therapeutic drugs by the US Food and Drug Administration, and it is quite likely that the number of approved antibodies will double in the next 7–10 years. Antibody drugs show several desirable characteristics, including good solubility and stability, long persistence in the body, high selectivity and specificity, and low risk for bioconversion to toxic metabolites. However, many antibody drugs demonstrate attributes that complicate drug… CONTINUE READING
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