Monoclonal Antibody LpMab-9 Recognizes O-glycosylated N-Terminus of Human Podoplanin.

@article{Kaneko2015MonoclonalAL,
  title={Monoclonal Antibody LpMab-9 Recognizes O-glycosylated N-Terminus of Human Podoplanin.},
  author={Mika Kato Kaneko and Hiroharu Oki and Yasukazu Hozumi and Xing Liu and Satoshi Ogasawara and Michiaki Takagi and Katsutoshi Goto and Yukinari Kato},
  journal={Monoclonal antibodies in immunodiagnosis and immunotherapy},
  year={2015},
  volume={34 5},
  pages={
          310-7
        }
}
Podoplanin (PDPN) induces cell invasion and cancer metastasis, and its expression in cancer cells or cancer-associated fibroblasts has been reported to be involved in poor prognosis of several cancers including malignant gliomas and lung cancers. PDPN is also expressed in normal cells such as lymphatic endothelial cells, lung type I alveolar cells, and kidney podocytes. Many anti-PDPN monoclonal antibodies (MAbs) have been established; however, almost all anti-PDPN MAbs recognize a platelet… CONTINUE READING

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