Monoclonal Antibodies in Preclinical EAE Models of Multiple Sclerosis: A Systematic Review

@inproceedings{Schmitz2017MonoclonalAI,
  title={Monoclonal Antibodies in Preclinical EAE Models of Multiple Sclerosis: A Systematic Review},
  author={Katja Schmitz and Gerd 7 Geisslinger and Irmgard Tegeder},
  booktitle={International journal of molecular sciences},
  year={2017}
}
Monoclonal antibodies (mAb) are promising therapeutics in multiple sclerosis and multiple new candidates have been developed, hence increasing the need for some agreement for preclinical mAb studies. We systematically analyzed publications of experimental autoimmune encephalomyelitis (EAE) studies showing effects of monoclonal antibodies. A PubMed search retrieved 570 records, out of which 122 studies with 253 experiments were eligible based on experimental design, number of animals and… CONTINUE READING