Monoclonal Antibodies and Multifunctional Cytochrome P450: Drug Metabolism as Paradigm

@article{Gelboin2006MonoclonalAA,
  title={Monoclonal Antibodies and Multifunctional Cytochrome P450: Drug Metabolism as Paradigm},
  author={H. Gelboin and K. Krausz},
  journal={The Journal of Clinical Pharmacology},
  year={2006},
  volume={46}
}
Monoclonal antibodies are reagents par excellence for analyzing the role of individual cytochrome P450 isoforms in multifunctional biological activities catalyzed by cytochrome P450 enzymes. The precision and utility of the monoclonal antibodies have heretofore been applied primarily to studies of human drug metabolism. The unique and precise specificity and high inhibitory activity toward individual cytochrome P450s make the monoclonal antibodies extraordinary tools for identifying and… Expand
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