Monoclonal Antibodies Specific for Human IgE-Producing B Cells: A Potential Therapeutic for IgE-Mediated Allergic Diseases

@article{Chang1990MonoclonalAS,
  title={Monoclonal Antibodies Specific for Human IgE-Producing B Cells: A Potential Therapeutic for IgE-Mediated Allergic Diseases},
  author={Tse Wen Chang and Frances M. Davis and N. C. Sun and Cecily R. Y. Sun and Donald W MacGlashan and Robert G. Hamilton},
  journal={Bio/Technology},
  year={1990},
  volume={8},
  pages={122-126}
}
Monoclonal antibodies (MAbs) specific for surface antigens of lymphocytes are being used to target and deplete tumorous or normal lymphocytes in vivo. Here, we report evidence for the existence of antigenic epitopes on IgE that are accessible on IgE-secreting B cells but not on other cells bearing IgE. Among 42 murine MAbs specific for human IgE, two were shown by fluorescence flow cytometric analyses to bind to IgE-secreting cell lines but not to IgE bound to high-affinity IgE. Fc receptors… 
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