Monoclonal Anti-human Factor

  title={Monoclonal Anti-human Factor},
  author={George J. Broze and Scot Hickman and Joseph P. Miletich},
Several murine monoclonal anti-human Factor VII antibodies were produced using hybridoma technology. Two noncompetitive monoclonal antibodies were used to examine by Western blotting the Factor VII cross-reactive material (CRM) in normal human plasma and three commercially available congenitally Factor VIIdeficient plasmas, and to construct a facile "sandwich" immunoassay for plasma Factor VII. A second, previously undescribed, form of Factor VII CRMwas detected in human plasma, which on… CONTINUE READING