Monochromosome transfer and microarray analysis identify a critical tumor-suppressive region mapping to chromosome 13q14 and THSD1 in esophageal carcinoma.

@article{Ko2008MonochromosomeTA,
  title={Monochromosome transfer and microarray analysis identify a critical tumor-suppressive region mapping to chromosome 13q14 and THSD1 in esophageal carcinoma.},
  author={Josephine Mun Yee Ko and Pui Ling Chan and Wing Lung Yau and Ho Kin Chan and King Chi Chan and Zhuo You Yu and Fung Mei Kwong and Lance D. Miller and Edison T. Liu and Li Chun Yang and Paulisally Hau Yi Lo and Eric John Stanbridge and Johnny Cheuk On Tang and Gopesh Srivastava and Sai Wah Tsao and S-L. Law and Maria Li Lung},
  journal={Molecular cancer research : MCR},
  year={2008},
  volume={6 4},
  pages={
          592-603
        }
}
Loss of chromosome 13q regions in esophageal squamous cell carcinoma (ESCC) is a frequent event. Monochromosome transfer approaches provide direct functional evidence for tumor suppression by chromosome 13 in SLMT-1, an ESCC cell line, and identify critical regions at 13q12.3, 13q14.11, and 13q14.3. Differential gene expression profiles of three tumor-suppressing microcell hybrids (MCH) and their tumorigenic parental SLMT-1 cell line were revealed by competitive hybridization using 19k cDNA… CONTINUE READING
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Functional evidence of decreased TABLE 2. Details of RT-PCR and THSD1 MSP Analysis and Bisulfite Sequencing Primer Sequences Gene Nucleotide Positions Size (bp) Primer Sequences

  • JM Ko, WL Yau, PL Chan
  • GAPDH
  • 2008
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