Monochloramine selectively inhibits the transient outward potassium current in colonic smooth muscle.

Abstract

BACKGROUND During colitis, activated neutrophils elaborate biologically active oxidants into the bowel wall. Colonic contraction, governed by plasma membrane ion channels in smooth muscle cells (SMCs), is markedly abnormal in colitis. The transient outward K(+) current (I(TO)) is an important determinant of electrical excitability in colonic SMCs. The aim… (More)

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