Monochloramine induces contraction of guinea pig gallbladder via two different pathways.

@article{Moummi1991MonochloramineIC,
  title={Monochloramine induces contraction of guinea pig gallbladder via two different pathways.},
  author={C Moummi and Gary W. Gullikson and Timothy S. Gaginella},
  journal={The American journal of physiology},
  year={1991},
  volume={260 6 Pt 1},
  pages={G881-6}
}
The purpose of the present investigation was to examine the effect and mechanism of action of the reactive oxygen metabolites monochloramine (NH2Cl), hypochlorous acid (HOCl), and hydrogen peroxide (H2O2) on gallbladder smooth muscle contractility. All oxidants caused concentration-dependent increases in resting tension of gallbladder muscle; the rank order of potencies (half-maximal concentration) was NH2Cl (30 microM) greater than HOCl (70 microM) greater than H2O2 (100 microM). The oxidant… CONTINUE READING

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