Monochloramine induced DNA fragmentation in gastric cell line MKN45.

  title={Monochloramine induced DNA fragmentation in gastric cell line MKN45.},
  author={Hidekazu Suzuki and Koichi Seto and Mikiji Mori and Masayuki Suzuki and Soichiro Miura and Hiromasa Ishii},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={275 4},
Monochloramine (NH2Cl) is known to be one of the virulence factors in Helicobacter pylori-associated gastric mucosal injury. The present study was designed to examine NH2Cl-evoked DNA fragmentation in the gastric epithelial cell line MKN45. NH2Cl was produced by mixing NH3 with sodium hypochlorite (NaClO). MKN45 cells were exposed to NH2Cl, NH3, or NaClO in Hanks' balanced salt solution. DNA cleavage was evaluated quantitatively by photometeric enzyme immunoassay for the in vitro determination… CONTINUE READING

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