Monocarboxylate transporters in the brain and in cancer☆

  title={Monocarboxylate transporters in the brain and in cancer☆},
  author={Jhudit P{\'e}rez-Escuredo and Vincent F. Van H{\'e}e and Martina Sboarina and Jorge Falces and Val{\'e}ry L. Payen and Luc Pellerin and Pierre Sonveaux},
  booktitle={Biochimica et biophysica acta},
Monocarboxylate transporters (MCTs) constitute a family of 14 members among which MCT1-4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and ketone bodies together with protons across cell membranes. Their anchorage and activity at the plasma membrane requires interaction with chaperon protein such as basigin/CD147 and embigin/gp70. MCT1-4 are expressed in different tissues where they play important roles in physiological and pathological processes. This review… CONTINUE READING