Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets.

@article{MirandaGonalves2013MonocarboxylateT,
  title={Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets.},
  author={Vera Miranda-Gonçalves and Mrinalini Honavar and C{\'e}line Pinheiro and Olga Martinho and Manuel Jorge Rocha Melo Pires and C{\'e}lia M Pinheiro and Michelle Cordeiro and Gil Bebiano and Paulo Albuquerque da Costa and Isabel Palmeirim and Rui Manuel Reis and F{\'a}tima Baltazar},
  journal={Neuro-oncology},
  year={2013},
  volume={15 2},
  pages={172-88}
}
BACKGROUND Gliomas exhibit high glycolytic rates, and monocarboxylate transporters (MCTs) play a major role in the maintenance of the glycolytic metabolism through the proton-linked transmembrane transport of lactate. However, their role in gliomas is poorly studied. Thus, we aimed to characterize the expression of MCT1, MCT4, and their chaperone CD147 and to assess the therapeutic impact of MCT inhibition in gliomas. METHODS MCTs and CD147 expressions were characterized by… CONTINUE READING

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