Monocarboxylate transporter 10 functions as a thyroid hormone transporter in chondrocytes.

@article{Abe2012MonocarboxylateT1,
  title={Monocarboxylate transporter 10 functions as a thyroid hormone transporter in chondrocytes.},
  author={Sanae Abe and Noriyuki Namba and Makoto Abe and Makoto T Fujiwara and Tomonao Aikawa and Mikihiko Kogo and Keiichi Ozono},
  journal={Endocrinology},
  year={2012},
  volume={153 8},
  pages={4049-58}
}
Thyroid hormone is essential for normal proliferation and differentiation of chondrocytes. Thus, untreated congenital hypothyroidism is marked by severe short stature. The monocarboxylate transporter 8 (MCT8) is a highly specific transporter for thyroid hormone. The hallmarks of Allan-Herndon-Dudley syndrome, caused by MCT8 mutations, are severe psychomotor retardation and elevated T(3) levels. However, growth is mostly normal. We therefore hypothesized that growth plate chondrocytes use… CONTINUE READING

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