Monobenzone‐induced depigmentation: from enzymatic blockade to autoimmunity

@article{vandenBoorn2011MonobenzoneinducedDF,
  title={Monobenzone‐induced depigmentation: from enzymatic blockade to autoimmunity},
  author={Jasper G. van den Boorn and Cornelis J. M. Melief and Rosalie M. Luiten},
  journal={Pigment Cell \& Melanoma Research},
  year={2011},
  volume={24}
}
Autoimmune side‐effects such as vitiligo regularly occur during melanoma immunotherapy. As vitiligo development is associated with a superior prognosis, the active induction of vitiligo in melanoma patients can be a useful tactic. The potent skin‐depigmenting agent monobenzone can be used successfully for this purpose. However, until recently, the mechanism of action behind monobenzone‐induced skin depigmentation was unclear. Lately, the mechanistic basis for the augmented immunogenicity of… 

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