Monobenzone‐induced depigmentation: from enzymatic blockade to autoimmunity

@article{Boorn2011MonobenzoneinducedDF,
  title={Monobenzone‐induced depigmentation: from enzymatic blockade to autoimmunity},
  author={J. G. van den Boorn and C. Melief and R. Luiten},
  journal={Pigment Cell & Melanoma Research},
  year={2011},
  volume={24}
}
Autoimmune side‐effects such as vitiligo regularly occur during melanoma immunotherapy. As vitiligo development is associated with a superior prognosis, the active induction of vitiligo in melanoma patients can be a useful tactic. The potent skin‐depigmenting agent monobenzone can be used successfully for this purpose. However, until recently, the mechanism of action behind monobenzone‐induced skin depigmentation was unclear. Lately, the mechanistic basis for the augmented immunogenicity of… Expand
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References

SHOWING 1-10 OF 84 REFERENCES
Skin-depigmenting agent monobenzone induces potent T-cell autoimmunity toward pigmented cells by tyrosinase haptenation and melanosome autophagy.
[Acquired leukomelanoderma caused by topical depigmenting agents].
Contact hypersensitivity to monobenzyl ether of hydroquinone used to treat vitiligo
On the etiology of contact/occupational vitiligo.
Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity.
Hypopigmenting agents: an updated review on biological, chemical and clinical aspects.
Mechanism of depigmentation by hydroquinone.
Evaluation of monobenzone.
...
1
2
3
4
5
...