Monoamines, BDNF, IL-6 and corticosterone in CSF in patients with Parkinson’s disease and major depression

@article{Plhagen2009MonoaminesBI,
  title={Monoamines, BDNF, IL-6 and corticosterone in CSF in patients with Parkinson’s disease and major depression},
  author={Sven E. P{\aa}lhagen and Hongshi Qi and Bj{\"o}rn M{\aa}rtensson and Jan W{\aa}linder and A. -K. Gran{\'e}rus and Per Svenningsson},
  journal={Journal of Neurology},
  year={2009},
  volume={257},
  pages={524-532}
}
The biochemical basis of major depression (MD) in Parkinson’s disease (PD) is largely unknown. To increase our understanding of MD in PD patients, the levels of monoamine metabolites (HVA, 5-HIAA and MHPG), BDNF, orexin-A, IL-6 and corticosterone were examined in cerebrospinal fluid. The analyses were performed in MD patients with (n = 11) and without (n = 12) PD at baseline and after 12 weeks’ of treatment with the antidepressant citalopram, and in patients with solely PD (n = 14) at baseline… CONTINUE READING
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Treatment of major depression in Parkinson’s disease improves depressive as well as motor symptoms—indicating a more extensive neurodegenerative process

  • SE Pålhagen, J Wålinder, AK Granérus
  • 2009
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