Monoaminergic neuropathology in Alzheimer's disease.


None of the proposed mechanisms of Alzheimer's disease (AD) fully explains the distribution patterns of the neuropathological changes at the cellular and regional levels, and their clinical correlates. One aspect of this problem lies in the complex genetic, epigenetic, and environmental landscape of AD: early-onset AD is often familial with autosomal… (More)
DOI: 10.1016/j.pneurobio.2016.04.001