Monoaminergic dysfunction in recreational users of dexamphetamine

@article{Schouw2013MonoaminergicDI,
  title={Monoaminergic dysfunction in recreational users of dexamphetamine},
  author={M. L. J. Schouw and M.W.A. Caan and Hanneke E Hulst Ralph HB Benedict Martijn D Steenwijk Menn Geurts and Ben A. Schmand and Jan Booij and Aart J. Nederveen and L. Reneman},
  journal={European Neuropsychopharmacology},
  year={2013},
  volume={23},
  pages={1491-1502}
}
Preclinical studies suggest that dexamphetamine (dAMPH) can lead to monoaminergic neurotoxicity. This exploratory study aimed to investigate effects of recreational dAMPH use on the dopamine (DA) and noradrenaline (NA) systems in humans. To that purpose, eight male abstinent dAMPH (26.0 ± 4.0 years) users and 10 age- and IQ-matched male healthy control subjects (23.0 ± 3.8) underwent neuropsychological testing sensitive to DAergic function and single photon emission computed tomography (SPECT… CONTINUE READING

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In addition , CBF in control subjects decreased significantly in response to MPH in gray matter and basal ganglia , among which the striatum , thalamus and hippocampus by 10% to 29% .
In addition , CBF in control subjects decreased significantly in response to MPH in gray matter and basal ganglia , among which the striatum , thalamus and hippocampus by 10% to 29% .
In addition , CBF in control subjects decreased significantly in response to MPH in gray matter and basal ganglia , among which the striatum , thalamus and hippocampus by 10% to 29% .
Corpus striatum structureAnatomic structure is physical part ofBasal Ganglia
In addition , CBF in control subjects decreased significantly in response to MPH in gray matter and basal ganglia , among which the striatum , thalamus and hippocampus by 10% to 29% .
This exploratory study aimed to investigate effects of recreational dAMPH use on the dopamine ( DA ) and noradrenaline ( NA ) systems in humans .
This exploratory study aimed to investigate effects of recreational dAMPH use on the dopamine ( DA ) and noradrenaline ( NA ) systems in humans .
DopamineSibling in is aNorepinephrine
This exploratory study aimed to investigate effects of recreational dAMPH use on the dopamine ( DA ) and noradrenaline ( NA ) systems in humans .
NorepinephrineSibling in is aDopamine
This exploratory study aimed to investigate effects of recreational dAMPH use on the dopamine ( DA ) and noradrenaline ( NA ) systems in humans .
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