Monoaminergic Orchestration of Motor Programs in a Complex C. elegans Behavior

  title={Monoaminergic Orchestration of Motor Programs in a Complex C. elegans Behavior},
  author={Jamie L. Donnelly and Christopher Michael Clark and Andrew M. Leifer and Jennifer K Pirri and Marian Haburcak and Michael M Francis and Aravinthan D. T. Samuel and Mark J. Alkema},
  booktitle={PLoS biology},
Monoamines provide chemical codes of behavioral states. However, the neural mechanisms of monoaminergic orchestration of behavior are poorly understood. Touch elicits an escape response in Caenorhabditis elegans where the animal moves backward and turns to change its direction of locomotion. We show that the tyramine receptor SER-2 acts through a Gαo pathway to inhibit neurotransmitter release from GABAergic motor neurons that synapse onto ventral body wall muscles. Extrasynaptic activation of… CONTINUE READING
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