Monoamine transporter and receptor interaction profiles of a new series of designer cathinones

@article{Simmler2014MonoamineTA,
  title={Monoamine transporter and receptor interaction profiles of a new series of designer cathinones},
  author={Linda D. Simmler and Anna Rickli and Marius C. Hoener and Matthias E. Liechti},
  journal={Neuropharmacology},
  year={2014},
  volume={79},
  pages={152-160}
}

Monoamine Transporter and Receptor Interaction Profiles of Synthetic Cathinones

TLDR
There are considerable differences among cathinones with respect to potencies and relative activity at monoaminergic targets, and in vitro screening and pharmacological classification are essential in providing translationally valuable information promptly after new cathinone derivatives emerge among drug users.

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Cathinones with a nitrogen-containing pyrrolidine ring emerged as NPS that are extremely potent transporter inhibitors but not monoamine releasers, suggesting more stimulant and reinforcing properties.

Hazard Characterization of Synthetic Cathinones Using Viability, Monoamine Reuptake, and Neuronal Activity Assays

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The combination of integrated measurements (MEA recordings of neuronal activity) with single target assays (monoamine reuptake transporter inhibition) indicates inhibition of hDAT and hNET as the primary mode of action of these synthetic cathinones.
...

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