Monoamine receptor sensitivity changes following chronic administration of MDL 72394, a site-directed inhibitor of monoamine oxidase.

@article{Palfreyman1986MonoamineRS,
  title={Monoamine receptor sensitivity changes following chronic administration of MDL 72394, a site-directed inhibitor of monoamine oxidase.},
  author={M. Palfreyman and A. Mir and M. Kubina and D. Middlemiss and M. Richards and M. Tricklebank and J. Fozard},
  journal={European journal of pharmacology},
  year={1986},
  volume={130 1-2},
  pages={
          73-89
        }
}
  • M. Palfreyman, A. Mir, +4 authors J. Fozard
  • Published 1986
  • Chemistry, Medicine
  • European journal of pharmacology
  • (E)-beta-Fluoromethylene-m-tyrosine (MDL 72394) is not per se an inhibitor of monoamine oxidase (MAO) but is a substrate of aromatic L-amino acid decarboxylase (AADC) which liberates the potent MAO inhibitor (E)-beta-fluoromethylene-m-tyramine (MDL 72392). When co-administered to animals with the peripherally selective AADC inhibitor, carbidopa, MDL 72394 inhibited MAO selectively in the brain. Chronic (14 days plus 3 days withdrawal) administration of 0.5 mg/kg per day p.o. MDL 72394, 0.1 mg… CONTINUE READING
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