Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs)
@article{Luethi2018MonoamineRI, title={Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs)}, author={Dino Luethi and Daniel Trachsel and Marius C. Hoener and Matthias E. Liechti}, journal={Neuropharmacology}, year={2018}, volume={134}, pages={141-148} }
29 Citations
Receptor Interaction Profiles of 4-Alkoxy-Substituted 2,5-Dimethoxyphenethylamines and Related Amphetamines
- Chemistry, BiologyFront. Pharmacol.
- 2019
4-alkyloxy-substituted 2,5-dimethoxyamphetamines and Phenethylamines share some trends with the many other phenethylamine pharmacophore containing compounds, such as when increasing the size of the 4- substituent and increasing the lipophilicity, the affinities at the 5-HT2A/C subtype also increase, and only weak 5- HT2A or C subtype selectivities were achieved.
Monoamine receptor interaction profiles of 4-aryl-substituted 2,5-dimethoxyphenethylamines (2C-BI derivatives).
- Chemistry, BiologyEuropean journal of pharmacology
- 2019
Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines
- Biology, ChemistryFrontiers in Pharmacology
- 2021
3,4,5-Trimethoxyphenethylamine (mescaline) is a psychedelic alkaloid found in peyote cactus and scalines and 3C-scalines interacted with the 5-HT2A and 5- HT2C receptors and bound with higher affinities when compared to mescaline, with no potent affinity observed at non-serotonergic targets.
Pharmacological characterization of 3,4-methylenedioxyamphetamine (MDA) analogs and two amphetamine-based compounds: N,α-DEPEA and DPIA
- Biology, ChemistryEuropean Neuropsychopharmacology
- 2022
Metabolites of the ring-substituted stimulants MDMA, methylone and MDPV differentially affect human monoaminergic systems
- Biology, ChemistryJournal of psychopharmacology
- 2019
Several metabolites of MDMA, methylone and MDPV interact with human transporters and receptors at pharmacologically relevant concentrations and could contribute to the in vivo activity of the parent compounds in human users.
Pharmacological characterization of the aminorex analogs 4-MAR, 4,4'-DMAR, and 3,4-DMAR.
- Biology, ChemistryNeurotoxicology
- 2019
Effects of the new psychoactive substances diclofensine, diphenidine, and methoxphenidine on monoaminergic systems
- Biology, ChemistryEuropean journal of pharmacology
- 2018
The Pharmacological Profile of Second Generation Pyrovalerone Cathinones and Related Cathinone Derivative
- Biology, ChemistryInternational journal of molecular sciences
- 2021
4F-PBP and NEH were selective DAT/NET inhibitors indicating that pyrovalerone and related cathinone derivatives likely produce strong psychostimulant effects and have a high abuse liability.
Dibenzofuranylethylamines as 5-HT2A/2C Receptor Agonists
- Chemistry, BiologyACS omega
- 2020
Five phenethylamine analogs in which the benzene ring is replaced by a bulky dibenzo[b,d]furan moiety are synthesized and found a couple with >70-fold 5-HT2C selectivity.
The psychostimulant (±)-cis-4,4′-dimethylaminorex (4,4′-DMAR) interacts with human plasmalemmal and vesicular monoamine transporters
- Biology, ChemistryNeuropharmacology
- 2018
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