Monoamine oxidase inhibitory activities of indolylalkaloid toxins from the venom of the colonial spider Parawixia bistriata: functional characterization of PwTX-I.

@article{Saidemberg2009MonoamineOI,
  title={Monoamine oxidase inhibitory activities of indolylalkaloid toxins from the venom of the colonial spider Parawixia bistriata: functional characterization of PwTX-I.},
  author={Daniel Menezes Saidemberg and Marco A B Ferreira and Tatiane N Takahashi and Paulo C{\'e}sar Gomes and Lilian M M C{\'e}sar-Tognoli and Luiz Carlos da Silva-Filho and Cl{\'a}udio Francisco Tormena and Gil Valdo Jos{\'e} da Silva and M{\'a}rio S{\'e}rgio Palma},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2009},
  volume={54 6},
  pages={
          717-24
        }
}
Colonial spiders evolved a differential prey-capture behaviour in concert with their venom chemistry, which may be a source of novel drugs. Some highly active tetrahydro-beta-carboline (THbetaC) toxins were recently isolated from the venom of the colonial spider Parawixia bistriata; the spiders use these toxins as part of their chemical arsenal to kill and/or paralyze preys. The major THbetaC compound isolated from this venom was identified as 6-hydroxytrypargine, also known as PwTX-I. Most… 
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