Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion.

BACKGROUND Long-lasting effects of withdrawal from nicotine are hypothesized to contribute to relapse and persistence of tobacco habits, and significant evidence supports a role of monoamine oxidase inhibitors (MAOI) contained in cigarette smoke as potent modulators of the rewarding effects of tobacco. METHODS With quantification of somatic signs of… CONTINUE READING