Monoamine oxidase a polymorphism in Brazilian patients: risk factor for late-onset Alzheimer's disease?

@article{Nishimura2005MonoamineOA,
  title={Monoamine oxidase a polymorphism in Brazilian patients: risk factor for late-onset Alzheimer's disease?},
  author={Agnes Lumi Nishimura and Camila Santa Cruz Guindalini and Jo{\~a}o Ricardo M. Oliveira and Ricardo Nitrini and Val{\'e}ria Santoro Bahia and Paulo Roberto de Brito-Marques and Paulo A Otto and Mayana Zatz},
  journal={Journal of molecular neuroscience : MN},
  year={2005},
  volume={27 2},
  pages={213-7}
}
Different studies have attempted to find polymorphisms involved in the serotonergic pathway that could be involved in mood disorders and late-onset Alzheimer's disease (LOAD) symptoms. Here, we compared the frequency of two polymorphisms: monoamine oxidase A (MAOA) and serotonin transporter in LOAD patients versus controls. No evidence of association was observed when these polymorphisms were compared separately; however, the combination of the MAOA allele 1+the short allele of 5-HTTLPR+ApoE… CONTINUE READING

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