Monoamine oxidase B and free radical scavenging activities of natural flavonoids in Melastoma candidum D. Don.

  title={Monoamine oxidase B and free radical scavenging activities of natural flavonoids in Melastoma candidum D. Don.},
  author={M. H. Lee and R. Lin and L. Y. Shen and L. L. Yang and K. Yen and W. Hou},
  journal={Journal of agricultural and food chemistry},
  volume={49 11},
  • M. H. Lee, R. Lin, +3 authors W. Hou
  • Published 2001
  • Chemistry, Medicine
  • Journal of agricultural and food chemistry
Monoamine oxidase type B (MAO-B) activity and free radicals are elevated in certain neurological diseases. Four natural flavonoids, quercitrin, isoquercitrin, rutin, and quercetin, were isolated for the first time from the leaves of Melastoma candidum D. Don. They exhibited an inhibitory effect on MAO-B. These potent flavonoids were purified using bioassay-guided fractionation and were separated by Diaion, Sephadex LH-20, and MCI CHP20P columns. The IC(50) values of the four potent flavonoids… Expand
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