Monoamine oxidase B, smoking, and Parkinson's disease.

  title={Monoamine oxidase B, smoking, and Parkinson's disease.},
  author={V. Wee Yong and Thomas L. Perry},
  journal={Journal of the neurological sciences},
  volume={72 2-3},
Idiopathic Parkinson's disease (PD) has been reported to occur more commonly among non-smokers than among cigarette smokers, for reasons that are unknown. PD may possibly be caused by one or more unidentified neurotoxins which chemically resemble N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a substance which after conversion to an active neurotoxin by monoamine oxidase B (MAO-B) can extensively damage dopaminergic nigrostriatal neurons in humans, lower primates and mice. We measured MAO… CONTINUE READING
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