Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis.

  title={Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis.},
  author={Jason Boyang Wu and Chen Shao and Xiangyan Li and Qinlong Li and Peizhen Hu and Changhong Shi and Yang Li and Yi-Ting Chen and Fei Yin and Chun-Peng Liao and Bangyan L. Stiles and Haiyen E. Zhau and Jean Chen Shih and Leland W. K. Chung},
  journal={The Journal of clinical investigation},
  volume={124 7},
Tumors from patients with high-grade aggressive prostate cancer (PCa) exhibit increased expression of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine neurotransmitters and dietary amines. Despite the association between MAOA and aggressive PCa, it is unclear how MAOA promotes PCa progression. Here, we found that MAOA functions to induce epithelial-to-mesenchymal transition (EMT) and stabilize the transcription factor HIF1α, which mediates hypoxia through an elevation… CONTINUE READING