Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli.

@article{Agatsuma2006MonoamineOA,
  title={Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli.},
  author={Soh Agatsuma and Moonsook Lee and Hongwen Zhu and Kevin Chen and Jean Chen Shih and Isabelle Seif and Noboru Hiroi},
  journal={Human molecular genetics},
  year={2006},
  volume={15 18},
  pages={2721-31}
}
Nicotine is thought to act on brain monoamine systems that normally mediate diverse motivational behaviors. How monoamine-related genes contribute to behavioral traits (e.g. responses to novel stimuli) comorbid with the susceptibility to nicotine addiction is still poorly understood. We examined the impact of constitutive monoamine oxidase A (MAOA) deficiency in mice on nicotine reward and responses to novel stimuli. Age-matched, male Maoa-knockout (KO) mice and wild-type (WT) littermates were… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 112 references

Similar Papers

Loading similar papers…