Monoamine oxidase A gene polymorphisms and enzyme activity associated with risk of gout in Taiwan aborigines

  title={Monoamine oxidase A gene polymorphisms and enzyme activity associated with risk of gout in Taiwan aborigines},
  author={H. Tu and A. Ko and Shu-Jung Wang and Chien-Hung Lee and R. Lea and Shang-Lun Chiang and H. Chiang and Tsu-Nai Wang and Meng‐Chuan Huang and T. Ou and Gau-Tyan Lin and Y. Ko},
  journal={Human Genetics},
  • H. Tu, A. Ko, +9 authors Y. Ko
  • Published 2009
  • Biology, Medicine
  • Human Genetics
Taiwanese aborigines have a high prevalence of hyperuricemia and gout. Uric acid levels and urate excretion have correlated with dopamine-induced glomerular filtration response. MAOs represent one of the major renal dopamine metabolic pathways. We aimed to identify the monoamine oxidase A (MAOA, Xp11.3) gene variants and MAO-A enzyme activity associated with gout risk. This study was to investigate the association between gout and the MAOA single-nucleotide polymorphisms (SNPs) rs5953210… Expand
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