Monoamine oxidase A gene (MAOA) predicts behavioral aggression following provocation

@article{McDermott2009MonoamineOA,
  title={Monoamine oxidase A gene (MAOA) predicts behavioral aggression following provocation},
  author={Rose McDermott and Dustin Tingley and Jonathan Cowden and Giovanni Frazzetto and Dominic D. P. Johnson},
  journal={Proceedings of the National Academy of Sciences},
  year={2009},
  volume={106},
  pages={2118 - 2123}
}
Monoamine oxidase A gene (MAOA) has earned the nickname “warrior gene” because it has been linked to aggression in observational and survey-based studies. However, no controlled experimental studies have tested whether the warrior gene actually drives behavioral manifestations of these tendencies. We report an experiment, synthesizing work in psychology and behavioral economics, which demonstrates that aggression occurs with greater intensity and frequency as provocation is experimentally… 
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References

SHOWING 1-10 OF 54 REFERENCES

Understanding Genetic Risk for Aggression: Clues From the Brain’s Response to Social Exclusion

Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A.

Analytical results indicate that isolated complete MAOA deficiency in this family is associated with a recognizable behavioral phenotype that includes disturbed regulation of impulsive aggression.

From Genes to Brain to Antisocial Behavior

This review summarizes recent brain-imaging and molecular-genetic findings on antisocial, violent, and psychopathic behavior and highlights key brain regions implicated in antisocial behavior, with an emphasis on the prefrontal cortex, along with ways these areas give expression to risk factors for antissocial behavior.

Early Trauma and Increased Risk for Physical Aggression during Adulthood: The Moderating Role of MAOA Genotype

The hypothesis that MAOA genotype moderates the association between early traumatic life events experienced during the first 15 years of life and the display of physical aggression during adulthood is supported and the use of dimensional measures focusing on behavioral aspects of aggression may increase the likelihood of detecting significant gene-by-environment interactions in studies of MAOA-related aggression.

MAO-A and -B gene knock-out mice exhibit distinctly different behavior.

Stochastic studies of MAO-A and -B KO mice have clearly shown that MAO/B have distinct functions in neurotransmitter metabolism and behavior, and are valuable models for investigating the role of monoamines in aggression and neurodegenerative and stress-related disorders.

Evidence for positive selection and population structure at the human MAO-A gene

The analysis of human nucleotide diversity at a genetic locus known to be involved in a behavioral phenotype, the monoamine oxidase A gene, finds both a reduction in levels of diversity and an excess of high frequency-derived variants, as expected after a recent episode of positive selection.

A hot new way to measure aggression: Hot sauce allocation

Laboratory experiments investigating aggressive behavior have operationalized and assessed aggression in a variety of ways; however, these measures are often problematic because they do not create a…

Social Context in Gene-Environment Interactions: Retrospect and Prospect.

  • M. ShanahanS. Hofer
  • Psychology
    The journals of gerontology. Series B, Psychological sciences and social sciences
  • 2005
A typology is drawn on existing examples of GE interactions to formulate a set of generic mechanisms by which E moderates G, which call for the integration of life course sociology and behavioral genetics to foster ways of studying genes, context, and aging.

Terror management and aggression: evidence that mortality salience motivates aggression against worldview-threatening others.

The hypothesis that mortality salience motivates aggression against worldview-threatening others was tested and it was found that derogation and aggression are two alternative modes of responding to MS that serve the same psychological function.

Role of Genotype in the Cycle of Violence in Maltreated Children

A functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A was found to moderate the effect of maltreatment, and it was found that Maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems.
...