Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway.

@article{Ou2006MonoamineOA,
  title={Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway.},
  author={X M Ou and Kevin Chen and Jean Chen Shih},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 29},
  pages={10923-8}
}
Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death. We have previously reported that a novel transcription factor R1 (RAM2/CDCA7L/JPO2) inhibits the MAO A promoter and enzymatic activities. This study reports the roles of MAO A and R1 in apoptosis and proliferation. We have found that in serum starvation-induced apoptosis, p38 kinase, MAO A, and caspase-3 were increased, whereas Bcl-2 and R1 were reduced… CONTINUE READING