Monoamine oxidase: radiotracer chemistry and human studies.

  title={Monoamine oxidase: radiotracer chemistry and human studies.},
  author={Joanna S. Fowler and Jean Logan and Elena Shumay and Nelly Alia-Klein and Gene-Jack Wang and Nora D. Volkow},
  journal={Journal of labelled compounds & radiopharmaceuticals},
  volume={58 3},
Monoamine oxidase (MAO) oxidizes amines from both endogenous and exogenous sources thereby regulating the concentration of neurotransmitter amines such as serotonin, norepinephrine, and dopamine as well as many xenobiotics. MAO inhibitor drugs are used in the treatment of Parkinson's disease and in depression stimulating the development of radiotracer tools to probe the role of MAO in normal human biology and in disease. Over the past 30 years since the first radiotracers were developed and the… CONTINUE READING
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