Monoamine oxidase: from genes to behavior.

  title={Monoamine oxidase: from genes to behavior.},
  author={Jean Chen Shih and Kevin Chen and M J Ridd},
  journal={Annual review of neuroscience},
Cloning of MAO (monoamine oxidase) A and B has demonstrated unequivocally that these enzymes are made up of different polypeptides, and our understanding of MAO structure, regulation, and function has been significantly advanced by studies using their cDNA. MAO A and B genes are located on the X-chromosome (Xp11.23) and comprise 15 exons with identical intron-exon organization, which suggests that they are derived from the same ancestral gene. MAO A and B knock-out mice exhibit distinct… CONTINUE READING
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