Monoamine oxidase: A gene polymorphism, tryptophan hydroxylase gene polymorphism and antidepressant response to fluvoxamine in Japanese patients with major depressive disorder.

@article{Yoshida2002MonoamineOA,
  title={Monoamine oxidase: A gene polymorphism, tryptophan hydroxylase gene polymorphism and antidepressant response to fluvoxamine in Japanese patients with major depressive disorder.},
  author={Keizo Yoshida and Shingo Naito and Hitoshi Takahashi and Kazuhiro Sato and Kenichi Ito and Mitsuhiro Kamata and Hisashi Higuchi and Tetsuo Shimizu and Kunihiko Itoh and Kazuyuki Inoue and Takehiko Tezuka and Toshio Suzuki and Tadashi Ohkubo and Kazunobu Sugawara and Koichi Otani},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2002},
  volume={26 7-8},
  pages={1279-83}
}
Monoamine oxidase A (MAOA) and tryptophan hydroxylase (TPH) are the staple enzymes in the metabolism of serotonin (5-HT). The genetic polymorphisms of these two enzymes might individually alter the production, release, reuptake or degradation of 5-HT during the treatment of selective serotonin reuptake inhibitors (SSRIs), leading to the individual differences in the antidepressant effects of SSRIs. The authors investigated whether a functional polymorphism in the MAOA gene promoter (MAOA-VNTR… CONTINUE READING

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