Monoamine depletion studies: implications for antidepressant discontinuation syndrome.

  title={Monoamine depletion studies: implications for antidepressant discontinuation syndrome.},
  author={Pedro L. Delgado},
  journal={The Journal of clinical psychiatry},
  volume={67 Suppl 4},
The likelihood of a connection between serotonin reuptake inhibitor (SRI) discontinuation and an acute reduction in synaptic serotonin (5-HT) has ignited interest in the similarities between SRI discontinuation syndrome and the symptoms observed after acute tryptophan depletion, which reduces synaptic 5-HT levels. An open question is whether these 2 phenomena have shared characteristics because of a similar underlying mechanism. The evidence in support of a similar underlying mechanism includes… CONTINUE READING

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