Monoamine depletion in unmedicated depressed subjects.

  title={Monoamine depletion in unmedicated depressed subjects.},
  author={Robert M. Berman and Gerard S Sanacora and Amit Anand and Lisa M Roach and Madonna K Fasula and Catherine O Finkelstein and R Mathew Wachen and Dan A. Oren and George R. Heninger and Dennis S. Charney},
  journal={Biological psychiatry},
  volume={51 6},
BACKGROUND Although significant evidence suggests that diminished monoamine function is associated with clinical depression, catecholamine or indoleamine depletion alone has not been associated with significant mood changes in unmedicated depressed subjects or never-depressed control subjects. This study assesses the integrated role of these monoamine systems in depressed patients. METHODS Unmedicated depressed subjects underwent a 2-week, double-blind, random-ordered crossover study… CONTINUE READING

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