Monoamine Transporter Occupancy of a Novel Triple Reuptake Inhibitor in Baboons and Humans Using Positron Emission Tomography

@article{Comley2013MonoamineTO,
  title={Monoamine Transporter Occupancy of a Novel Triple Reuptake Inhibitor in Baboons and Humans Using Positron Emission Tomography},
  author={Robert A. Comley and Cristian A. Salinas and Mark Slifstein and Marcella Petrone and Carmine Marzano and Idriss Bennacef and Paul Shotbolt and Jasper van der Aart and Marta Neve and Laura E. Iavarone and Roberto Gomeni and Marc Laruelle and Frank A. Gray and Roger N. Gunn and Eugenii A. Rabiner},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  year={2013},
  volume={346},
  pages={311 - 317}
}
The selection of a therapeutically meaningful dose of a novel pharmaceutical is a crucial step in drug development. Positron emission tomography (PET) allows the in vivo estimation of the relationship between the plasma concentration of a drug and its target occupancy, optimizing dose selection and reducing the time and cost of early development. Triple reuptake inhibitors (TRIs), also referred to as serotonin-norepinephrine-dopamine reuptake inhibitors, enhance monoaminergic neurotransmission… 

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