Monoamine Oxidase A and Catechol-O-Methyltransferase Functional Polymorphisms and the Placebo Response in Major Depressive Disorder

  title={Monoamine Oxidase A and Catechol-O-Methyltransferase Functional Polymorphisms and the Placebo Response in Major Depressive Disorder},
  author={Andrew F. Leuchter and James T. McCracken and A M Hunter and Ian A Cook and Jonathan E. Alpert},
  journal={Journal of Clinical Psychopharmacology},
The placebo response shows pronounced interindividual variability. Placebos are postulated to act through central reward pathways that are modulated by monoamines. Because monoaminergic signaling is under strong genetic control, we hypothesized that common functional polymorphisms modulating monoaminergic tone would be related to degree of improvement during placebo treatment of subjects with major depressive disorder. We examined polymorphisms in genes encoding the catabolic enzymes catechol-O… 

Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome

The hypothesis that the COMT functional val158met polymorphism is a potential biomarker of placebo response is supported and data support this hypothesis.

Catechol-O-Methyltransferase val 158 met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome

The hypothesis that the COMT val158met polymorphism is a potential biomarker of placebo response is supported and data support this hypothesis in a subset of 104 patients from a previously reported randomized controlled trial in irritable bowel syndrome.

Monoamine Oxidase A (MAOA) and Catechol-O-Methyltransferase (COMT) Gene Polymorphisms Interact with Maternal Parenting in Association with Adolescent Reactive Aggression but not Proactive Aggression: Evidence of Differential Susceptibility

Findings provide the first evidence for distinct G × E interaction effects on reactive versus proactive aggression and lend further support for the differential susceptibility hypothesis.

Influence of catechol-O-methyltransferase Val158Met on fear of pain and placebo analgesia

The Met-allele seems to be associated with the negative emotional process of fear, but not with placebo analgesia, in what appears to be inconsistent findings in the literature.

Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Somatosensory Amplification and Nocebo Responses

Together these data demonstrate potential genetic and psychological variables predicting nocebo responses after drug and placebo intake, which might be utilized to minimizeNocebo effects in clinical trials and medical practice.

Association study of monoamine oxidase A/B genes and schizophrenia in Han Chinese

The results suggest that MAOB is a susceptibility gene for schizophrenia and no significant associations were observed for the MAOA functional polymorphism with schizophrenia in Han Chinese, which support further investigation of the role of MAO genes in schizophrenia.

Interacting Effect of Catechol-O-Methyltransferase (COMT) and Monoamine Oxidase A (MAOA) Gene Polymorphisms, and Stressful Life Events on Aggressive Behavior in Chinese Male Adolescents

The first evidence of COMT × MAOA × SLE interaction effect on male adolescents’ aggressive behavior is presented, highlighting the importance of considering distinct domains of stressful events and information bias when examining the effect of MAOA and COMT on aggressive behavior, and contributes to MAOA gene-aggression andCOMT gene- Aggression literature.

Analysis of 34 candidate genes in bupropion and placebo remission.

A possible role for HTR2A in remission to bupropion treatment is suggested, and dopamine transporter may play a role in response in patients with major depressive disorder.

Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A

Variation in tyramine pharmacokinetics and pharmacodynamics is not explained by obvious genomic variation, and human tyramsine metabolism did not indicate the existence of ultra-low or -high MAO-A activity.



Association Study of a Monoamine Oxidase A Gene Promoter Polymorphism with Major Depressive Disorder and Antidepressant Response

The findings suggest that the MAOA-uVNTR may be involved in the pathogenesis of MDD and the antidepressant therapeutic mechanisms in Chinese population, and that there may be a gender effect in this association.

The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes

It is hypothesized that the COMT Met allele (associated with low enzyme activity) results in increased levels of tonic DA and reciprocal reductions in phasic DA in subcortical regions and increased D1 transmission cortically.

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.

The identification of a gentic marker associated with significant alterations in enzyme activity will facilitate the analysis of a possible role for the COMT gene in neuropsychiatric conditions in which abnormalities in catecholamine neurotransmission are believed to occur.

Association analysis between a functional polymorphism in the monoamine oxidase A gene promoter and severe mood disorders

The results suggest that MAOA gene variation may modulate the expression of some clinical aspects of severe mood disorders, especially in females, and support the existence of a genetic and aetiologic heterogeneity underlying the diagnoses of bipolar disorder and major depression.

Monoamine Oxidase A Genotype Predicts Human Serotonin 1A Receptor Availability In Vivo

A sex-specific interaction between two key molecules of the human serotonergic system is demonstrated, and a neurobiological basis for sexual dimorphism in serotonin-modulated phenotypes is suggested.

Association between monoamine oxidase gene polymorphisms and smoking behaviour in Chinese males.

There is an important association between MAOA polymorphisms and smoking status, suggesting a possible role of MAOA gene variants in nicotine dependence.

Investigation of serotonin-related genes in antidepressant response

Results implicate TPH1 and SLC6A4 in general response, and HTR2A, TPH2, and MAOA in the specificity of response to fluoxetine, and a number of the less frequent alleles of many of the SNP markers were associated with the nonresponse and nonspecific phenotypes.

Human monoamine oxidase A gene determines levels of enzyme activity.

Monoamine oxidase (MAO) is a critical enzyme in the degradative deamination of biogenic amines throughout the body. Two biochemically distinct forms of the enzyme, A and B, are encoded in separate

Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens.

Smokers with genes associated with low resting dopamine tone have greater smoking-induced (phasic) dopamine release than those with alternate genotypes, and these findings suggest that dopamine system genotype variabilities explain a significant proportion of the interindividual variability insmoking-induced dopamine release.

The MAOA T941G polymorphism and short‐term treatment response to mirtazapine and paroxetine in major depression

  • A. TadićM. J. Müller A. Szegedi
  • Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2007
Time course of response and antidepressant efficacy of mirtazapine, but not paroxetine, seem to be influenced in a clinically relevant manner by this allelic variation within the MAOA gene, at least in female patients.