Monoallelic expression of Krt12 gene during corneal-type epithelium differentiation of limbal stem cells.

Abstract

PURPOSE The purpose of this study was to characterize a Krt12-Cre knock-in mouse line for corneal epithelium-specific gene ablation and to analyze the allelic selection of the keratin 12 (Krt12) gene during corneal type-epithelium differentiation. METHODS Knock-in mice were generated by gene targeting. The authors examined the expression patterns of… (More)
DOI: 10.1167/iovs.10-5331

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