Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex

@inproceedings{Schofield2010MonoallelicDO,
  title={Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex},
  author={Claude M. Schofield and Ruby Hsu and Alison J. Barker and Caitlyn C. Gertz and Robert Blelloch and Erik M Ullian},
  booktitle={Neural Development},
  year={2010}
}
Neuronal phenotypes associated with hemizygosity of individual genes within the 22q11.2 deletion syndrome locus hold potential towards understanding the pathogenesis of schizophrenia and autism. Included among these genes is Dgcr8, which encodes an RNA-binding protein required for microRNA biogenesis. Dgcr8 haploinsufficient mice (Dgcr8+/-) have reduced expression of microRNAs in brain and display cognitive deficits, but how microRNA deficiency affects the development and function of neurons in… CONTINUE READING

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Dysregulation of presynaptic calcium and synaptic plasticity in a mouse model of 22q11 deletion syndrome.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010
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