Monoacylglycerols Activate TRPV1 – A Link between Phospholipase C and TRPV1

@article{Zygmunt2013MonoacylglycerolsAT,
  title={Monoacylglycerols Activate TRPV1 – A Link between Phospholipase C and TRPV1},
  author={P. Zygmunt and Anna Ermund and P. Movahed and D. Andersson and C. Simonsen and B. Jönsson and A. Blomgren and B. Birnir and S. Bevan and A. Eschalier and C. Mallet and A. Gomis and E. H{\"o}gest{\"a}tt},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
Phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate generates diacylglycerol, inositol 1,4,5-trisphosphate and protons, all of which can regulate TRPV1 activity via different mechanisms. Here we explored the possibility that the diacylglycerol metabolites 2-arachidonoylglycerol and 1-arachidonoylglycerol, and not metabolites of these monoacylglycerols, activate TRPV1 and contribute to this signaling cascade. 2-Arachidonoylglycerol and 1-arachidonoylglycerol activated… Expand
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References

SHOWING 1-10 OF 96 REFERENCES
Bradykinin Stimulates Arachidonic Acid Release Through the Sequential Actions of an sn‐1 Diacylglycerol Lipase and a Monoacylglycerol Lipase
TLDR
Analysis of the molecular species profiles of individual phospholipids in DRG neurons indicated that phosphoinositide hydrolysis may account for a significant portion of the rapid increase in content of 1‐stea‐royl‐2‐arachidonoyl diacylglycerol. Expand
Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes.
TLDR
This enzyme assay provides a useful method for future inhibition studies of 2-AG degrading enzyme(s) in brain membrane preparation having considerably higher MGL-like activity when compared to FAAH activity. Expand
Oxygenation of the Endocannabinoid, 2-Arachidonylglycerol, to Glyceryl Prostaglandins by Cyclooxygenase-2*
TLDR
Results identify a distinct function for COX-2 in endocannabinoid metabolism and in the generation of a new family of prostaglandins derived from diacylglycerol and 2-AG. Expand
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
TLDR
It is shown that the endocannabinoid anandamide and its metabolite arachidonic acid activate TRPV4 in an indirect way involving the cytochrome P450 epoxygenase-dependent formation of epoxyeicosatrienoic acids. Expand
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
TLDR
2-AG endogenously modulates several behavioral processes classically associated with the pharmacology of cannabinoids and point to overlapping and unique functions for 2-AG and anandamide in vivo, indicating a functional segregation of endocannabinoid signaling pathways in vivo. Expand
Signal-dependent Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate without Activation of Phospholipase C
TLDR
A narrow range of possible mechanisms for TRPL gating is defined, suggesting that PI(4,5)P2 is a crucial substrate for PLC-mediated activation of the channels, whereas PUFA may function as the channel activator. Expand
TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids
TLDR
It is shown that association of the TRPV1 C terminus with the bilayer modulates channel gating, consistent with phylogenetic data implicating this domain as a key regulatory site for tuning stimulus sensitivity, relevant to understanding how membrane lipids modulate other "receptor-operated" TRP channels. Expand
Dual Regulation of TRPV1 by Phosphoinositides
TLDR
It is concluded that phosphoinositides have both inhibitory and activating effects on TRPV1, resulting in complex and distinct regulation at various stimulation levels. Expand
Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors.
TLDR
These studies clearly indicate that 2-AG and other related compounds may function as agonists on VR1 receptors, as well as CB1 and CB2 receptors, and implicated these factors in various HBEC functions. Expand
Evidence That the Cannabinoid CB1 Receptor Is a 2-Arachidonoylglycerol Receptor
TLDR
The results strongly suggested that the cannabinoid CB1 receptor is originally a 2-arachidonoylglycerol receptor, and 2-Arachidonoyslglycersol is the intrinsic physiological ligand for the cannabinoidCB1 receptor. Expand
...
1
2
3
4
5
...