Monoacylglycerol lipase promotes progression of hepatocellular carcinoma via NF-κB-mediated epithelial-mesenchymal transition

@inproceedings{Zhu2016MonoacylglycerolLP,
  title={Monoacylglycerol lipase promotes progression of hepatocellular carcinoma via NF-κB-mediated epithelial-mesenchymal transition},
  author={Weiping Zhu and Yiming Zhao and Jiamin Zhou and Xin Wei Wang and Qi Pan and Ning Zhang and L Wang and Miao Wang and Dihua Zhan and Zeyang Liu and Xigan He and Dening Ma and Shuang Liu and Lu Wang},
  booktitle={Journal of Hematology & Oncology},
  year={2016}
}
BackgroundMonoacylglycerol lipase (MAGL), a critical lipolytic enzyme, has emerged as a key regulator of tumor progression, yet its biological function and clinical significance in hepatocellular carcinoma (HCC) is still unknown.MethodsIn this study, we used a tissue microarray containing samples from 170 HCC patients to evaluate the expression of MAGL and its correlation with other clinicopathologic characteristics. In addition, we investigated the regulating effects of MAGL on various HCC… CONTINUE READING
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