Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice.

@article{Quistad2006MonoacylglycerolLI,
  title={Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice.},
  author={Gary B. Quistad and Rebecka Klintenberg and Pierluigi Caboni and Shannon N Liang and John E. Casida},
  journal={Toxicology and applied pharmacology},
  year={2006},
  volume={211 1},
  pages={78-83}
}
Three components of the cannabinoid system are sensitive to selected organophosphorus (OP) compounds: monoacylglycerol (MAG) lipase that hydrolyzes the major endogenous agonist 2-arachidonoylglycerol (2-AG); fatty acid amide hydrolase (FAAH) that cleaves the agonist anandamide present in smaller amounts; the CB1 receptor itself. This investigation considers which component of the cannabinoid system is the most likely contributor to OP-induced hypomotility in mice. Structure-activity studies by… CONTINUE READING

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