Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling

@article{Zhong2014MonoacylglycerolLI,
  title={Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling},
  author={Peng Zhong and Wei Wang and Bin Pan and Xiaojie Liu and Zhenhua Zhang and Jonathan Z. Long and Han Zhang and Benjamin F Cravatt and Qing-Song Liu},
  journal={Neuropsychopharmacology},
  year={2014},
  volume={39},
  pages={1763-1776}
}
The endocannabinoid (eCB) system regulates mood, emotion, and stress coping, and dysregulation of the eCB system is critically involved in pathophysiology of depression. The eCB ligand 2-arachidonoylglycerol (2-AG) is inactivated by monoacylglycerol lipase (MAGL). Using chronic unpredictable mild stress (CUS) as a mouse model of depression, we examined how… CONTINUE READING