Mono-unsaturated fatty acids link H 3 K 4 me 3 modifiers to C . elegans lifespan

@inproceedings{Han2017MonounsaturatedFA,
  title={Mono-unsaturated fatty acids link H 3 K 4 me 3 modifiers to C . elegans lifespan},
  author={Shuo Han and Elizabeth A. Schroeder and Carlos Giovanni Silva-Garc{\'i}a and Katja Hebestreit and William B. Mair and Anne Brunet},
  year={2017}
}
Chromatin state, which encompasses post-translational modification of histone proteins, integrates environmental signals to influence gene expression and downstream cellular processes. Enzymes that deposit or remove histone modifications regulate lifespan in several species1,2. For example, methyltransferase or demethylase complexes that modify H3K4me3, H3K27me3 and H3K36me3 modulate lifespan in yeast, worms and flies1,2. Several chromatin-modifying enzymes require intracellular metabolites as… CONTINUE READING