Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish.

@article{Gerlach2014MonosubstitutedIT,
  title={Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish.},
  author={Cory V Gerlach and Siba Ranjan Das and David C Volz and William H. Bisson and Siva Kumar Kolluri and Robert L. Tanguay},
  journal={Aquatic toxicology},
  year={2014},
  volume={154},
  pages={71-9}
}
Firemaster 550 (FM550) is an additive flame retardant mixture used within polyurethane foam and is increasingly found in house dust and the environment due to leaching. Despite the widespread use of FM550, very few studies have investigated the potential toxicity of its ingredients during early vertebrate development. In the current study, we sought to specifically investigate mono-substituted isopropylated triaryl phosphate (mITP), a component comprising approximately 32% of FM550, which has… CONTINUE READING
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