Mono-hydroxyeicosatetraenoic acids during porcine endotoxemia. Effect of a platelet-activating factor receptor antagonist.

@article{Olson1990MonohydroxyeicosatetraenoicAD,
  title={Mono-hydroxyeicosatetraenoic acids during porcine endotoxemia. Effect of a platelet-activating factor receptor antagonist.},
  author={N C Olson and Paul B. M. Joyce and Lloyd N. Fleisher},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1990},
  volume={63 2},
  pages={221-32}
}
Infusion of endotoxin into domestic pigs induces an acute respiratory failure that has many similarities with the adult respiratory distress syndrome. We hypothesized that mono-hydroxyeicosatetraenoic acids (HETE) and platelet-activating factor (PAF) might be involved in this model of respiratory failure. Escherichia coli endotoxin (055-B5) was infused intravenously into anesthetized young pigs at 5 micrograms/kg the first hour, followed by 2 micrograms/kg/hour for 3 hours in the presence and… CONTINUE READING